Alpha GPC: Benefits, Dosage And Side Effects

Smiling woman sitting holding alpha gpc and glass of water

Written by Jordan Caulfield & Reviewed by Paul Holmes.

In today's world, more of us are starting to think long-term when it comes to our health. It’s not just about going to the gym or eating well anymore; it’s also about taking care of our brain, and also how to live a healthier, longer life.

Brain health is becoming just as important as physical fitness, especially as we look ahead to the future. One supplement in particular that’s been in the spotlight lately is Alpha GPC. You may have heard of it already, maybe in a podcast, a health blog, or even from a friend who is into nootropics.

But what exactly are the primary Alpha GPC benefits? And is it worth adding to your routine? In this guide, we’re going to provide a deep dive into Alpha GPC, what it does, recommended dosage, potential side effects and much more. And of course, we’ll touch on how our Alpha GPC capsules may be a simple way to support your cognitive and physical health each day.

    What Is Alpha GPC?

    Let’s start with the basics. Alpha GPC, or ‘L-Alpha Glycerylphosphorylcholine’, is a naturally occurring compound in the body that contains choline. Choline is an essential nutrient that plays a key role in brain function. What makes Alpha GPC stand out is how easily it crosses the blood-brain barrier.

    Once it’s in your system, it gets to work quickly by increasing levels of acetylcholine, a neurotransmitter that helps with memory, learning, and even muscle control. Most Alpha GPC used in supplements is derived from soy or sunflower lecithin. It’s popular in nootropic stacks, pre-workout, and daily wellness routines.

    Why Is Alpha GPC Important?

    Our bodies require choline to function efficiently, particularly our brains. But we don’t always get enough from our diet alone. And when choline levels drop, we might start to feel the effects, such as brain fog, forgetfulness, and lack of focus.

    Alpha GPC helps keep things running smoothly by feeding the brain what it needs to stay sharp and alert. This becomes even more important as we get older, since natural choline levels tend to decline with age.

    Some signs you might benefit from Alpha GPC support include:

    • Struggling to focus for long periods
    • Feeling mentally drained after work or study
    • Noticing memory lapses or forgetfulness
    • Wanting to improve brain longevity and performance
    Woman holding head with a headache looking at computer screen

    3 Alpha GPC Benefits

    Here are the main benefits people experience when taking Alpha GPC:

    1. Memory And Brain Function

    One of the most talked-about Alpha GPC benefits is its potential ability to support memory. Choline is important for brain and nervous system function; thereby enhancing it, you can help to support this over time.

    2. Focus And Learning

    Whether you’re studying for an exam, in back-to-back meetings, or working on a creative project, Alpha GPC may help you stay focused and absorb information more by supporting brain function.

    3. Liver Function

    It’s not just important for brain function. Alpha-GPC is a source of choline, a nutrient that contributes to normal lipid metabolism and liver function

    Alpha GPC: What Do The Studies Say?

    Here’s a quick look at some of the ongoing research behind Alpha GPC:

    Cognitive Decline In Older Adults

    A study published in Mechanisms of Ageing and Development looked at elderly individuals with dementia. After taking Alpha GPC daily for six months, they showed notable improvements in memory and orientation compared to those who took a placebo [1].

    Potential Boost In Athletic Performance 

    In a small but promising trial, resistance-trained men who took 600 mg of Alpha GPC before training showed a significant increase in strength compared to the placebo group [2]. It’s one reason why it’s popping up in pre-workout blends. However, more research is needed in this area to fully understand its potential and application.

    Neurological Conditions Like Epilepsy

    Some experimental studies[3] are investigating how Alpha GPC may help manage neurological conditions, such as epilepsy, due to its ability to support neurotransmitter activity. The research is still in its early stages, but it shows some promise.

    Man in vest lifting weights in the gym

    Alpha GPC And Choline: What’s The Link?

    To understand why Alpha GPC works so effectively, it's crucial to discuss choline. Choline is a nutrient your body uses to make acetylcholine, a chemical messenger that keeps your brain and nervous system firing on all cylinders.

    It also helps support liver function and metabolism. Alpha GPC is one of the most efficient ways to increase choline levels because it’s highly bioavailable. Meaning your body can absorb and use it quickly, especially compared to other choline sources like CDP-choline or phosphatidylcholine.

    Alpha GPC Dosage: How Much Should You Take?

    The correct dosage of Alpha GPC depends on what you’re using it for:

    • For cognitive health: 300–600mg per day
    • For liver health: Around 600mg, taken before a meal

    You can take Alpha GPC with or without food, though some people find it easier on the stomach when taken with a meal. Our Alpha GPC capsules are designed to make daily support simple, no measuring, no mixing, just straightforward health support when you need it most.

    Alpha GPC Side Effects

    Most people tolerate Alpha GPC well, but like any supplement, it’s not entirely free from potential side effects.

    Here are a few things to look out for:

    • Mild headaches
    • Nausea
    • Digestive discomfort
    • Difficulty sleeping (if taken late in the day)

    To minimise side effects, start with a lower dose and work your way up if needed. And as always, speak to a healthcare provider if you’re unsure.

    Woman in floral dress sitting at desk struggling to concentrate

    Are There Natural Ways To Increase Choline?

    While Alpha GPC itself isn’t commonly found in food, you can increase your choline intake through:

    • Eggs (especially yolks)
    • Beef liver
    • Fish (like salmon and cod)
    • Soybeans
    • Chicken and turkey

    That said, it’s often tricky to reach the choline levels needed for noticeable brain benefits through food alone, so a targeted supplement can help fill the gap.

    Foods on wooden board that help increase choline

    FAQS About Alpha GPC

    When is the best time to take Alpha GPC?
    It depends on your goals. For brain health, mornings are great. For liver function, with food.

    Can Alpha GPC be taken alongside medication?
    If you’re taking any medications or have a medical condition, it’s best to check with your doctor before starting Alpha GPC or any new supplement.

    Conclusion

    Whether you’re chasing better focus at work, sharper memory, or enhanced liver function, Alpha GPC is a supplement definitely worth considering. It’s backed by promising science, used by athletes and everyday people alike, and helps support your brain health and longevity over time.

    If you’re looking for an easy way to add Alpha GPC to your wellness routine, our Alpha GPC capsules at Naturecan are a convenient, high-quality option.

    They’re part of our wider Brain Health Collection, crafted to support a happier, sharper, and healthier future.

    References

    1. Parnetti, L. et al. (2001). Choline alphoscerate in cognitive decline and in acute cerebrovascular disease: an analysis of published clinical data. Mechanisms of Ageing and Development, 122(16), pp.2041–2055. Available at: https://pubmed.ncbi.nlm.nih.gov/11589921/

    2. Ziegenfuss, T. N. et al. (2008). Effects of an oral alpha-GPC supplement on performance and growth hormone. Journal of the International Society of Sports Nutrition, 5(1), p.19. Available at: https://jissn.biomedcentral.com/articles/10.1186/1550-2783-5-S1-P15#citeas

    3. Lee SH, Choi BY, Kim JH, Kho AR, Sohn M, Song HK, Choi HC, Suh SW. Late treatment with choline alfoscerate (l-alpha glycerylphosphorylcholine, α-GPC) increases hippocampal neurogenesis and provides protection against seizure-induced neuronal death and cognitive impairment. Available at: https://pubmed.ncbi.nlm.nih.gov/27765578/